Chemicals and Drugs

Nimustine

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

Chemical Identity

Chemical Information

Molecular Formula
C9H13ClN6O2
Molecular Weight
272.69 g/mol
CAS Registry No.
42471-28-3
IUPAC Name
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea
InChIKey
VFEDRRNHLBGPNN-UHFFFAOYSA-N
SMILES
CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O
MeSH Unique ID
D015376
Source
PubChem CID 39214

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • ACNU
  • NSC 245382

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Antineoplastic Agents (1975-1988)
  • Nitrosourea Compounds (1975-1988)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.950w.594.550w
  2. D02w.654.692.550w

AMA Style

References

  1. National Library of Medicine. Nimustine. Medical Subject Headings (MeSH). 2026. Unique ID D015376. http://id.nlm.nih.gov/mesh/2026/D015376
  2. Nimustine. In: Wikipedia. https://en.wikipedia.org/wiki/Nimustine
  3. Nimustine. In: Wikidata. https://www.wikidata.org/wiki/Q907623
  4. Nimustine. In: PubChem Compound. CID 39214. https://pubchem.ncbi.nlm.nih.gov/compound/39214