Chemicals and Drugs

Nicardipine

A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.

Chemical Identity

Chemical Information

Molecular Formula
C26H29N3O6
Molecular Weight
479.5 g/mol
CAS Registry No.
55985-32-5
IUPAC Name
5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey
ZBBHBTPTTSWHBA-UHFFFAOYSA-N
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
MeSH Unique ID
D009529
Source
PubChem CID 4474

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

22 entry terms
  • Antagonil
  • Cardene
  • Cardene I.V.
  • Cardene SR
  • Dagan
  • Flusemide
  • Lecibral
  • Lincil
  • Loxen
  • Lucenfal
  • Nicardipine Hydrochloride
  • Nicardipine LA
  • Nicardipino Ratiopharm
  • Nicardipino Seid
  • Perdipine
  • Ridene
  • Vasonase
  • Y-93
  • Hydrochloride, Nicardipine
  • LA, Nicardipine
  • Y 93
  • Y93

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Nifedipine/analogs & derivatives (1975-1986)
  • Pyridines (1966-1974)

MeSH Hierarchy

Tree Number

  1. D03w.383.725w.203.510w

MeSH Record

NLM Classification

QV 151

AMA Style

References

  1. National Library of Medicine. Nicardipine. Medical Subject Headings (MeSH). 2026. Unique ID D009529. http://id.nlm.nih.gov/mesh/2026/D009529
  2. Nicardipine. In: Wikipedia. https://en.wikipedia.org/wiki/Nicardipine
  3. Nicardipine. In: Wikidata. https://www.wikidata.org/wiki/Q729213
  4. Nicardipine. In: PubChem Compound. CID 4474. https://pubchem.ncbi.nlm.nih.gov/compound/4474