Neurotensin

A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.

Molecular Formula

C₇₈H₁₂₁N₂₁O₂₀

Molecular Weight

1672.9 g/mol

CAS Registry No.

39379-15-2

IUPAC Name

(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid

InChIKey

PCJGZPGTCUMMOT-ISULXFBGSA-N

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5

MeSH Unique ID

D009496

Source

PubChem CID 25077406

• Neurotensin Receptors

a neurotransmitter isolated from the hypothalamus; /biosyn /physiol permitted

78

• Kinins (1966-1977)
• Nerve Tissue Proteins (1966-1977)
• Peptides (1966-1977)

1. D12.644w.400w.550w
2. D12.776w.631w.650w.550w

WL 104

1. National Library of Medicine. Neurotensin. Medical Subject Headings (MeSH). 2026. Unique ID D009496. http://id.nlm.nih.gov/mesh/2026/D009496
2. Neurotensin. In: Wikipedia. https://en.wikipedia.org/wiki/Neurotensin
3. Neurotensin. In: Wikidata. https://www.wikidata.org/wiki/Q419576
4. Neurotensin. In: PubChem Compound. CID 25077406. https://pubchem.ncbi.nlm.nih.gov/compound/25077406