Chemicals and Drugs

Neuromuscular Nondepolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

13 entry terms
  • Curare-Like Agents
  • Curariform Drugs
  • Muscle Relaxants, Non-Depolarizing
  • Neuromuscular Blocking Agents, Competitive
  • Nondepolarizing Blockers
  • Agents, Curare-Like
  • Agents, Neuromuscular Nondepolarizing
  • Blockers, Nondepolarizing
  • Curare Like Agents
  • Drugs, Curariform
  • Muscle Relaxants, Non Depolarizing
  • Non-Depolarizing Muscle Relaxants
  • Nondepolarizing Agents, Neuromuscular

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was CURARE-LIKE AGENTS 1970-92; MUSCLE RELAXANTS, POLARIZING was see NEUROMUSCULAR NONDEPOLARIZING AGENTS 1989-94; NEUROMUSCULAR NONDEPOLARIZING AGENTS & PACHYCURARES were see CURARE-LIKE AGENTS 1975-92; CURARIFORM DRUGS was see under MUSCLE RELAXANTS 1963-69; MUSCLE RELAXANTS was see under CURARE-LIKE AGENTS & MUSCLE RELAXANTS, CENTRAL & NEUROMUSCULAR DEPOLARIZING AGENTS 1970-74, was heading 1963-69; CURARIFORM ANTAGONISTS was heading 1963-69

MeSH Record

Previous Indexing

  • Muscles (1966-1969)

MeSH Hierarchy

Tree Number

  1. D27.505.696.663.700.710.575

MeSH Record

NLM Classification

QV 140

AMA Style

References

  1. National Library of Medicine. Neuromuscular Nondepolarizing Agents. Medical Subject Headings (MeSH). 2026. Unique ID D003473. http://id.nlm.nih.gov/mesh/2026/D003473
  2. Neuromuscular Nondepolarizing Agents. In: Wikidata. https://www.wikidata.org/wiki/Q50429959