Chemicals and Drugs

Neuroligins

Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.

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Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Neuroligin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2024

MeSH Record

Previous Indexing

  • Nerve Tissue Proteins (1992-2023)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.250.520w.894w
  2. D12.776w.395w.550w.200w.250.520w.894w
  3. D12.776w.543w.550w.200w.250.520w.894w
  4. D12.776w.631w.641w
  5. D23.050w.301.350w.250.520w.894w

AMA Style

References

  1. National Library of Medicine. Neuroligins. Medical Subject Headings (MeSH). 2026. Unique ID D000096785. http://id.nlm.nih.gov/mesh/2026/D000096785
  2. Neuroligins. In: Wikipedia. https://en.wikipedia.org/wiki/Neuroligin
  3. Neuroligins. In: Wikidata. https://www.wikidata.org/wiki/Q4316446