Chemicals and Drugs

Neurokinin A

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.

Chemical Identity

Chemical Information

Molecular Formula
C50H80N14O14S
Molecular Weight
1133.3 g/mol
IUPAC Name
(3S)-3-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
InChIKey
HEAUFJZALFKPBA-YRVBCFNBSA-N
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CN=CN2)N
MeSH Unique ID
D015288
Source
PubChem CID 13561815

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

3 entry terms
  • Neurokinin alpha
  • Neuromedin L
  • Substance K

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was SUBSTANCE K 1989-93; NEUROKININ A was see SUBSTANCE K 1989-93

MeSH Record

Previous Indexing

  • Kinins (1980-1988)
  • Neuropeptides (1987-1988)
  • Oligopeptides (1980-1986)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.812w.900w.500w
  2. D12.644w.400w.800w.500w
  3. D12.644w.456w.800w.500w
  4. D12.776w.467.812w.900w.500w
  5. D12.776w.631w.650w.800w.500w
  6. D23.469.050w.375w.850w.550w
  7. D23.529.812w.900w.500w

AMA Style

References

  1. National Library of Medicine. Neurokinin A. Medical Subject Headings (MeSH). 2026. Unique ID D015288. http://id.nlm.nih.gov/mesh/2026/D015288
  2. Neurokinin A. In: Wikipedia. https://en.wikipedia.org/wiki/Neurokinin_A
  3. Neurokinin A. In: Wikidata. https://www.wikidata.org/wiki/Q408566
  4. Neurokinin A. In: PubChem Compound. CID 13561815. https://pubchem.ncbi.nlm.nih.gov/compound/13561815