Chemicals and Drugs

Neural Cell Adhesion Molecule L1

A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

MeSH Record

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MeSH Record

Synonyms

16 entry terms
  • CALL Protein
  • CamL1 Gene Product
  • Cell Adhesion Molecule L1
  • Cell Surface Glycoprotein L1
  • F11 Glycoprotein
  • L1 Cell Adhesion Molecule
  • L1CAM
  • NGF-Inducible Glycoprotein
  • NILE Glycoprotein
  • NILE Protein
  • Nerve Growth Factor-Inducible Large External Glycoprotein
  • Neural Adhesion Molecule L1
  • Glycoprotein, NGF-Inducible
  • Glycoprotein, NILE
  • NGF Inducible Glycoprotein
  • Nerve Growth Factor Inducible Large External Glycoprotein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use NEURAL CELL ADHESION MOLECULE L1 (NM) 1983-2002; for NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1992-2002; for CALL PROTEIN use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1999-2002; for NILE PROTEIN use LEUCKCYTE L1 ANTIGEN COMPLEX (NM) 1996-2002

MeSH Record

Previous Indexing

  • Antigens, Surface (1992-2002)
  • Cell Adhesion Molecules, Neuronal (1992-2002)
  • Membrane Glycoproteins (1992-2002)
  • Neural Cell Adhesion Molecules (1996-2002)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.250.520w.578w
  2. D12.776w.395w.550w.200w.250.520w.578w
  3. D12.776w.543w.550w.200w.250.520w.578w
  4. D23.050w.301.350w.250.520w.578w

AMA Style

References

  1. National Library of Medicine. Neural Cell Adhesion Molecule L1. Medical Subject Headings (MeSH). 2026. Unique ID D039842. http://id.nlm.nih.gov/mesh/2026/D039842
  2. Neural Cell Adhesion Molecule L1. In: Wikipedia. https://en.wikipedia.org/wiki/Neural_cell_adhesion_molecule_L1
  3. Neural Cell Adhesion Molecule L1. In: Wikidata. https://www.wikidata.org/wiki/Q1437419