Chemicals and Drugs

Neprilysin

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

32 entry terms
  • Antigens, CD10
  • Antigens, Leukemia, Common Acute Lymphoblastic
  • Atriopeptidase
  • CALLA Antigen
  • CD10 Antigen
  • CD10 Antigens
  • Common Acute Lymphoblastic Leukemia Antigens
  • Endopeptidase-24.11
  • Enkephalin Dipeptidyl Carboxypeptidase
  • Enkephalinase
  • Enkephalinase-24.11
  • Kidney-Brush-Border Neutral Proteinase
  • Membrane Metallo-Endopeptidase
  • Neutral Endopeptidase
  • Neutral Endopeptidase 24.11
  • Thermolysin-Like Metalloendopeptidase
  • YGG-Forming Enzyme
  • Antigen, CD10
  • Carboxypeptidase, Enkephalin Dipeptidyl
  • Dipeptidyl Carboxypeptidase, Enkephalin
  • Endopeptidase 24.11
  • Endopeptidase 24.11, Neutral
  • Endopeptidase, Neutral
  • Enkephalinase 24.11
  • Enzyme, YGG-Forming
  • Kidney Brush Border Neutral Proteinase
  • Membrane Metallo Endopeptidase
  • Metallo-Endopeptidase, Membrane
  • Metalloendopeptidase, Thermolysin-Like
  • Neutral Proteinase, Kidney-Brush-Border
  • Thermolysin Like Metalloendopeptidase
  • YGG Forming Enzyme

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92

MeSH Record

Previous Indexing

  • Metalloproteinases (1987-1988)
  • Peptide Peptidohydrolases (1966-1987)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.480w.600
  2. D08.811w.277w.656w.675w.374w.600
  3. D23.050w.285.550
  4. D23.101w.140.500

AMA Style

References

  1. National Library of Medicine. Neprilysin. Medical Subject Headings (MeSH). 2026. Unique ID D015260. http://id.nlm.nih.gov/mesh/2026/D015260
  2. Neprilysin. In: Wikidata. https://www.wikidata.org/wiki/Q24724493