Chemicals and Drugs

Nefopam

Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

Chemical Identity

Chemical Information

Molecular Formula
C17H19NO
Molecular Weight
253.34 g/mol
CAS Registry No.
13669-70-0
IUPAC Name
5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine
InChIKey
RGPDEAGGEXEMMM-UHFFFAOYSA-N
SMILES
CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3
MeSH Unique ID
D009340
Source
PubChem CID 4450

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • Acupan
  • Ajan
  • Fenazoxine
  • Nefopam Hydrochloride
  • Silentan Nefopam
  • Hydrochloride, Nefopam
  • Nefopam, Silentan

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under OXAZOCINES 1975-90

MeSH Record

Previous Indexing

  • Azocines (1972-1974)
  • Benzene Derivatives (1972-1974)

MeSH Hierarchy

Tree Number

MeSH Record

NLM Classification

QV 95

AMA Style

References

  1. National Library of Medicine. Nefopam. Medical Subject Headings (MeSH). 2026. Unique ID D009340. http://id.nlm.nih.gov/mesh/2026/D009340
  2. Nefopam. In: Wikipedia. https://en.wikipedia.org/wiki/Nefopam
  3. Nefopam. In: Wikidata. https://www.wikidata.org/wiki/Q599052
  4. Nefopam. In: PubChem Compound. CID 4450. https://pubchem.ncbi.nlm.nih.gov/compound/4450