Phenomena and Processes

Necroptosis

A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION.

MeSH Record

Classification

Broader headings

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MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

do not confuse with NECROSIS the pathological process

MeSH Record

History Note

2020

MeSH Record

Previous Indexing

  • Necrosis (2005-2019)

MeSH Hierarchy

Tree Number

  1. G04.146w.954w.500w

AMA Style

References

  1. National Library of Medicine. Necroptosis. Medical Subject Headings (MeSH). 2026. Unique ID D000079302. http://id.nlm.nih.gov/mesh/2026/D000079302
  2. Necroptosis. In: Wikipedia. https://en.wikipedia.org/wiki/Necroptosis
  3. Necroptosis. In: Wikidata. https://www.wikidata.org/wiki/Q3346925