Chemicals and Drugs

Naltrexone

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

Chemical Identity

Chemical Information

Molecular Formula
C20H23NO4
Molecular Weight
341.4 g/mol
CAS Registry No.
16590-41-3
IUPAC Name
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
InChIKey
DQCKKXVULJGBQN-XFWGSAIBSA-N
SMILES
C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
MeSH Unique ID
D009271
Source
PubChem CID 5360515

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Antaxone
  • Celupan
  • EN-1639A
  • Nalorex
  • Naltrexone Hydrochloride
  • Nemexin
  • ReVia
  • Trexan
  • EN 1639A
  • EN1639A

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1986 (1976)

MeSH Record

Previous Indexing

  • Cyclopropanes (1973-1975)
  • Morphinans (1973-1974)
  • Naloxone/analogs & derivatives (1975)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.706w.550w
  2. D03w.605.497.750w.550w
  3. D03w.633.400.686.750w.550w
  4. D04w.615w.723w.795.706w.550w

MeSH Record

NLM Classification

QV 89

AMA Style

References

  1. National Library of Medicine. Naltrexone. Medical Subject Headings (MeSH). 2026. Unique ID D009271. http://id.nlm.nih.gov/mesh/2026/D009271
  2. Naltrexone. In: Wikipedia. https://en.wikipedia.org/wiki/Naltrexone
  3. Naltrexone. In: Wikidata. https://www.wikidata.org/wiki/Q409587
  4. Naltrexone. In: PubChem Compound. CID 5360515. https://pubchem.ncbi.nlm.nih.gov/compound/5360515