Chemicals and Drugs

Naloxone Drug Combination Buprenorphine

A pharmaceutical preparation that combines buprenorphine, an OPIOID ANALGESICS with naloxone, a NARCOTIC ANTAGONISTS to reduce the potential for NARCOTIC DEPENDENCE in the treatment of pain. It may also be used for OPIOID SUBSTITUTION THERAPY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pharmaceutical preparation that combines buprenorphine, an OPIOID ANALGESICS with naloxone, a NARCOTIC ANTAGONISTS to reduce the potential for NARCOTIC DEPENDENCE in the treatment of pain. It may also be used for OPIOID SUBSTITUTION THERAPY.

Chemical Identity

Chemical Information

Molecular Formula
C48H62N2O8
Molecular Weight
795.0 g/mol
CAS Registry No.
352020-56-5
IUPAC Name
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
InChIKey
SFNLWIKOKQVFPB-KZCPYJDTSA-N
SMILES
C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)(C(C)(C)C)O.C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O
MeSH Unique ID
D000069479
Source
PubChem CID 11274356

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Buprenorphine Naloxone
  • Buprenorphine Naloxone Drug Combination
  • Buprenorphine, Naloxone Drug Combination
  • Buprenorphine-Naloxone
  • Buprenorphine-Naloxone Combination
  • Buprenorphine-Naloxone Drug Combination
  • Buprenorphine Naloxone Combination
  • Combination, Buprenorphine-Naloxone
  • Combination, Buprenorphine-Naloxone Drug
  • Drug Combination, Buprenorphine-Naloxone
  • Naloxone, Buprenorphine
  • Suboxone

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2006)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.150w.500w
  2. D03w.132w.577.249.706w.275w
  3. D03w.605.497.150w.500w
  4. D03w.605.497.750w.275w
  5. D03w.633.400.686.150w.500w
  6. D03w.633.400.686.750w.275w
  7. D04w.615w.723w.795.150w.500w
  8. D04w.615w.723w.795.706w.275w
  9. D26.310w.352w

AMA Style

References

  1. National Library of Medicine. Naloxone Drug Combination Buprenorphine. Medical Subject Headings (MeSH). 2026. Unique ID D000069479. http://id.nlm.nih.gov/mesh/2026/D000069479
  2. Naloxone Drug Combination Buprenorphine. In: Wikipedia. https://en.wikipedia.org/wiki/Buprenorphine/naloxone
  3. Naloxone Drug Combination Buprenorphine. In: Wikidata. https://www.wikidata.org/wiki/Q25048068
  4. Naloxone Drug Combination Buprenorphine. In: PubChem Compound. CID 11274356. https://pubchem.ncbi.nlm.nih.gov/compound/11274356