Structured Summary
Abstract
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
65 entry terms
- NF-AT Proteins
- NFAT Proteins
- NFATC Proteins
- Nuclear Factor of Activated T-Cells, Cytoplasmic
- Nuclear Factors of Activated T-Cells
- Transcription Factor NF-AT
- NF AT Proteins
- NF-AT, Transcription Factor
- Nuclear Factor of Activated T Cells, Cytoplasmic
- Nuclear Factors of Activated T Cells
- Transcription Factor NF AT
- Transcription Factors, NFATC
- NF-AT3 Protein
- NF-AT4 Protein
- NF-ATc1 Protein
- NFAT Transcription Factor 1
- NFAT Transcription Factor 2
- NFAT Transcription Factor 3
- NFAT Transcription Factor 4
- NFAT Transcription Factor 5
- NFAT-1 Protein
- NFAT-2 Protein
- NFAT1 Protein
- NFAT2 Protein
- NFAT3 Protein
- NFAT4 Protein
- NFAT5 Protein
- NFATC1 Protein
- NFATC1 Transcription Factor
- NFATC2 Protein
- NFATC2 Transcription Factor
- NFATC3 Protein
- NFATC3 Transcription Factor
- NFATC4 Protein
- NFATC4 Transcription Factor
- NFATL1 Protein
- NFATx Protein
- NFATz Protein
- Nuclear Factor of Activated T-Cells 5 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
- OREBP Protein
- Osmotic Response Element Binding Protein
- TonEBP Protein
- Tonicity-Responsive Enhancer-Binding Protein
- Factor, NFATC1 Transcription
- Factor, NFATC2 Transcription
- Factor, NFATC3 Transcription
- NF AT3 Protein
- NF AT4 Protein
- NF ATc1 Protein
- NFAT 1 Protein
- NFAT 2 Protein
- Nuclear Factor of Activated T Cells 5 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein
- Tonicity Responsive Enhancer Binding Protein
- Transcription Factor, NFATC1
- Transcription Factor, NFATC2
- Transcription Factor, NFATC3
- Transcription Factor, NFATC4
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1993)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. NFATC Transcription Factors. Medical Subject Headings (MeSH). 2026. Unique ID D050778. http://id.nlm.nih.gov/mesh/2026/D050778
- NFATC Transcription Factors. In: Wikidata. https://www.wikidata.org/wiki/Q21124058