Structured Summary
Abstract
A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
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Classification
Broader headings
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Synonyms
7 entry terms
- NEDD-8 Protein
- Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
- Ubiquitin-like Protein NEDD8
- NEDD 8 Protein
- NEDD8, Ubiquitin-like Protein
- Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8
- Ubiquitin like Protein NEDD8
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Ubiquitins (1993-2017)
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Tree Number
AMA Style
References
- National Library of Medicine. NEDD8 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000075687. http://id.nlm.nih.gov/mesh/2026/D000075687
- NEDD8 Protein. In: Wikipedia. https://en.wikipedia.org/wiki/NEDD8
- NEDD8 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q6953444