Chemicals and Drugs

N-Acetylgalactosamine-4-Sulfatase

An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

14 entry terms
  • Arylsulfatase B
  • N-Acetylgalactosamine 4-Sulfatase
  • N-Acetylgalactosamine-4-sulfate Sulfatase
  • N-Acetylgalactosamine-4-sulphate Sulphatase
  • 4-Sulfatase, N-Acetylgalactosamine
  • N Acetylgalactosamine 4 Sulfatase
  • N Acetylgalactosamine 4 sulfate Sulfatase
  • N Acetylgalactosamine 4 sulphate Sulphatase
  • Sulfatase, N-Acetylgalactosamine-4-sulfate
  • Sulphatase, N-Acetylgalactosamine-4-sulphate
  • Arylsulfatase B1
  • Arylsulfatase B2
  • B1, Arylsulfatase
  • B2, Arylsulfatase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1999; for ARYLSULFATASE B use CHONDRO-4-SULFATASE 1975-1998; use N-ACETYLGALACTOSAMINE-4-SULFATASE (NM) 1988-1998

MeSH Record

Previous Indexing

  • Sulfatases (1988-1998)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.827w.070w.060w
  2. D08.811w.277w.352w.827w.180.175w.060w

AMA Style

References

  1. National Library of Medicine. N-Acetylgalactosamine-4-Sulfatase. Medical Subject Headings (MeSH). 2026. Unique ID D020051. http://id.nlm.nih.gov/mesh/2026/D020051
  2. N-Acetylgalactosamine-4-Sulfatase. In: Wikipedia. https://en.wikipedia.org/wiki/N-acetylgalactosamine-4-sulfatase
  3. N-Acetylgalactosamine-4-Sulfatase. In: Wikidata. https://www.wikidata.org/wiki/Q10814068