Structured Summary
Abstract
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In humans, PHOSPHOFRUCTOKINASE-1 in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause GLYCOGEN STORAGE DISEASE TYPE VII, also known as Tarui's disease.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
4 entry terms
- 6-Phosphofructokinase, Muscle Type
- Phosphofructo-1-kinase Isozyme A
- Phosphofructokinase-1, Muscle Type
- Phosphofructokinase 1, Muscle Type
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2002
MeSH Record
Previous Indexing
- 6-Phosphofructokinase (1977-2001)
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AMA Style
References
- National Library of Medicine. Muscle Type Phosphofructokinase-1. Medical Subject Headings (MeSH). 2026. Unique ID D025203. http://id.nlm.nih.gov/mesh/2026/D025203
- Muscle Type Phosphofructokinase-1. In: Wikipedia. https://en.wikipedia.org/wiki/PFKM
- Muscle Type Phosphofructokinase-1. In: Wikidata. https://www.wikidata.org/wiki/Q21120434