Diseases

Multiple System Atrophy

A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)

MeSH Record

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MeSH Record

Synonyms

11 entry terms
  • Multiple System Atrophy Syndrome
  • Multisystem Atrophy
  • Multisystemic Atrophy
  • Atrophies, Multisystem
  • Atrophies, Multisystemic
  • Atrophy, Multiple System
  • Atrophy, Multisystem
  • Atrophy, Multisystemic
  • Multiple System Atrophies
  • Multisystem Atrophies
  • Multisystemic Atrophies

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

a specific neurodegenerative syndrome complex; not for atrophy in other systems

MeSH Record

History Note

1998

MeSH Record

Previous Indexing

  • Autonomic Nervous System Diseases (1981-1997)
  • Brain Diseases (1981-1993)
  • Nervous System Diseases (1969-1997)
  • Shy-Drager Syndrome (1981-1997)

MeSH Hierarchy

Tree Numbers

  1. C10w.177.575w.550w
  2. C10w.228w.140w.079w.612w
  3. C10w.228w.662w.550w
  4. C10w.574w.928w.625w

AMA Style

References

  1. National Library of Medicine. Multiple System Atrophy. Medical Subject Headings (MeSH). 2026. Unique ID D019578. http://id.nlm.nih.gov/mesh/2026/D019578
  2. Multiple System Atrophy. In: Wikipedia. https://en.wikipedia.org/wiki/Multiple_system_atrophy
  3. Multiple System Atrophy. In: Wikidata. https://www.wikidata.org/wiki/Q1541975