Diseases

Mucopolysaccharidosis II

Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

19 entry terms
  • Gargoylism, Hunter Syndrome
  • Hunter Syndrome
  • Hunter Syndrome Gargoylism
  • Hunter's Syndrome
  • Mucopolysaccharidosis 2
  • Mucopolysaccharidosis Type 2
  • Mucopolysaccharidosis Type II
  • Hunters Syndrome
  • Syndrome, Hunter
  • Syndrome, Hunter's
  • I2S Deficiency
  • Iduronate 2-Sulfatase Deficiency
  • Iduronate Sulfatase Deficiency
  • Sulfoiduronate Sulfatase Deficiency
  • Deficiency, I2S
  • Deficiency, Iduronate 2-Sulfatase
  • Deficiency, Iduronate Sulfatase
  • Deficiency, Sulfoiduronate Sulfatase
  • Iduronate 2 Sulfatase Deficiency

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1992; for MUCOPOLYSACCHARIDOSIS 2 and HUNTER'S SYNDROME use LIPOCHONDRODYSTROPHY 1976-1991

MeSH Record

Previous Indexing

  • Mucopolysaccharidosis I (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. C10w.597.606.360w.455w.750w
  2. C16w.320w.322.500w.750w
  3. C16w.320w.400.525w.750w
  4. C16w.320w.565w.202w.715w.645w
  5. C16w.320w.565w.595w.600w.645w
  6. C17.300w.550w.575w.645w
  7. C18.452w.648w.202w.715w.645w
  8. C18.452w.648w.595w.600w.645w

AMA Style

References

  1. National Library of Medicine. Mucopolysaccharidosis II. Medical Subject Headings (MeSH). 2026. Unique ID D016532. http://id.nlm.nih.gov/mesh/2026/D016532
  2. Mucopolysaccharidosis II. In: Wikipedia. https://en.wikipedia.org/wiki/Hunter_syndrome
  3. Mucopolysaccharidosis II. In: Wikidata. https://www.wikidata.org/wiki/Q1529983