Chemicals and Drugs

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

Chemical Identity

Chemical Information

Molecular Formula
C16H24N2O2
Molecular Weight
276.37 g/mol
CAS Registry No.
7416-34-4
IUPAC Name
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
InChIKey
KLPWJLBORRMFGK-UHFFFAOYSA-N
SMILES
CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C
MeSH Unique ID
D008972
Source
PubChem CID 23897

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • Moban
  • Molindone Hydrochloride
  • Molindone Monohydrochloride
  • Hydrochloride, Molindone
  • Monohydrochloride, Molindone

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(72); was see under INDOLES 1972-90

MeSH Record

Previous Indexing

  • Antidepressive Agents (1966-1971)
  • Indoles (1966-1971)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.473.629w

AMA Style

References

  1. National Library of Medicine. Molindone. Medical Subject Headings (MeSH). 2026. Unique ID D008972. http://id.nlm.nih.gov/mesh/2026/D008972
  2. Molindone. In: Wikipedia. https://en.wikipedia.org/wiki/Molindone
  3. Molindone. In: Wikidata. https://www.wikidata.org/wiki/Q593166
  4. Molindone. In: PubChem Compound. CID 23897. https://pubchem.ncbi.nlm.nih.gov/compound/23897