Diseases

Mixed Connective Tissue Disease

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a speckled epidermal nuclear staining pattern on direct immunofluorescence.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a speckled epidermal nuclear staining pattern on direct immunofluorescence.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Connective Tissue Disease, Mixed
  • MCTD
  • Sharp Syndrome
  • Syndrome, Sharp

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

a specific disease entity; do not confuse with CONNECTIVE TISSUE DISEASES

MeSH Record

History Note

79

MeSH Record

Previous Indexing

  • Collagen Diseases (1972-1978)
  • Lupus Erythematosus, Systemic (1972-1978)
  • Scleroderma, Systemic (1972-1978)

MeSH Hierarchy

Tree Number

  1. C17.300w.540w

MeSH Record

NLM Classification

QZ 192

AMA Style

References

  1. National Library of Medicine. Mixed Connective Tissue Disease. Medical Subject Headings (MeSH). 2026. Unique ID D008947. http://id.nlm.nih.gov/mesh/2026/D008947
  2. Mixed Connective Tissue Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Mixed_connective_tissue_disease
  3. Mixed Connective Tissue Disease. In: Wikidata. https://www.wikidata.org/wiki/Q1622407