Chemicals and Drugs

Mitogen-Activated Protein Kinase 1

A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

16 entry terms
  • Extracellular Signal-Regulated Kinase 2
  • MAP Kinase 2
  • MAPK1 Mitogen-Activated Protein Kinase
  • MAPK2 Mitogen-Activated Protein Kinase
  • Mitogen-Activated Protein Kinase 2
  • p42 MAP Kinase
  • p42 MAPK
  • p42(Mapk)
  • p42(Mapk) Kinase
  • p42(Mitogen-Activated Protein Kinase)
  • Extracellular Signal Regulated Kinase 2
  • MAP Kinase, p42
  • MAPK1 Mitogen Activated Protein Kinase
  • MAPK2 Mitogen Activated Protein Kinase
  • Mitogen Activated Protein Kinase 1
  • Mitogen Activated Protein Kinase 2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases

MeSH Record

History Note

2005(1992)

MeSH Record

Previous Indexing

  • Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1997)
  • Protein Kinases (1992)
  • Protein-Serine-Threonine Kinases (1993-1995)
  • Protein-Tyrosine Kinase (1992-1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.567w.249w.500
  2. D12.776w.476.563w.567w.249w.500

AMA Style

References

  1. National Library of Medicine. Mitogen-Activated Protein Kinase 1. Medical Subject Headings (MeSH). 2026. Unique ID D019950. http://id.nlm.nih.gov/mesh/2026/D019950
  2. Mitogen-Activated Protein Kinase 1. In: Wikidata. https://www.wikidata.org/wiki/Q6590503