Phenomena and Processes

Mitochondrial Transmembrane Permeability-Driven Necrosis

A form of regulated cell death that is initiated by specific perturbations of the intracellular microenvironment such as severe OXIDATIVE STRESS and cytosolic CALCIUM overload, which result in osmotic breakdown of the MITOCHONDRIAL MEMBRANES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of regulated cell death that is initiated by specific perturbations of the intracellular microenvironment such as severe OXIDATIVE STRESS and cytosolic CALCIUM overload, which result in osmotic breakdown of the MITOCHONDRIAL MEMBRANES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • Mitochondrial Transmembrane Permeability-Driven Cell Death
  • Mitochondrial Transmembrane Permeability Driven Cell Death
  • Mitochondrial Transmembrane Permeability Driven Necrosis
  • Mitochondrial Permeability Transition

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2020

MeSH Record

Previous Indexing

  • Cell Death (1993-2019)

MeSH Hierarchy

Tree Number

  1. G04.146w.954w.393

AMA Style

References

  1. National Library of Medicine. Mitochondrial Transmembrane Permeability-Driven Necrosis. Medical Subject Headings (MeSH). 2026. Unique ID D000079530. http://id.nlm.nih.gov/mesh/2026/D000079530
  2. Mitochondrial Transmembrane Permeability-Driven Necrosis. In: Wikidata. https://www.wikidata.org/wiki/Q114385064