Chemicals and Drugs

Mitochondrial Precursor Protein Import Complex Proteins

Multiprotein complexes that mediate import and sorting of mitochondrial preproteins into one of the four mitochondrial subcompartments: the outer membrane, the intermembrane space, the inner membrane, and the matrix. Mitochondrial protein import machinery includes translocase of the outer membrane (TOM) complex, translocases of the inner membrane (TIM) complex, beta‐barrel pathway complex, the mitochondrial intermembrane space import and assembly (MIA) pathway complex, carrier proteins of the inner membrane and the TIM23 complex and sorting and assembly machinery (SAM) complex.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Multiprotein complexes that mediate import and sorting of mitochondrial preproteins into one of the four mitochondrial subcompartments: the outer membrane, the intermembrane space, the inner membrane, and the matrix. Mitochondrial protein import machinery includes translocase of the outer membrane (TOM) complex, translocases of the inner membrane (TIM) complex, beta‐barrel pathway complex, the mitochondrial intermembrane space import and assembly (MIA) pathway complex, carrier proteins of the inner membrane and the TIM23 complex and sorting and assembly machinery (SAM) complex.

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Synonyms

27 entry terms
  • Mitochondrial Precursor Protein Import Machinery Proteins
  • Mitochondrial Protein Import Machinery Proteins
  • MIA Complex
  • MIM Complex
  • Mitochondrial Import Complex
  • Mitochondrial Intermembrane Space Import and Assembly Complex
  • Mitochondrial Preprotein Translocases
  • SAM Complex
  • Sorting and Assembly Machinery Complex
  • TIM Complex
  • TIM23 Complex
  • TIMM Complex
  • TOM Channel
  • TOM Complex
  • TOM Translocase
  • TOMM Complex
  • TOMM Machinery
  • Translocase Outer Mitochondrial Membrane
  • Translocase of the Inner Membrane Complex
  • Translocase of the Inner Mitochondrial Membrane Complex
  • Translocase of the Outer Membrane Complex
  • Translocases of the Inner Membrane 23 Complex
  • Translocases of the Inner Membrane Complex
  • Import Complex, Mitochondrial
  • Preprotein Translocases, Mitochondrial
  • Translocase, TOM
  • Translocases, Mitochondrial Preprotein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2022(2006)

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AMA Style

References

  1. National Library of Medicine. Mitochondrial Precursor Protein Import Complex Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000090622. http://id.nlm.nih.gov/mesh/2026/D000090622
  2. Mitochondrial Precursor Protein Import Complex Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q110877500