Structured Summary
Abstract
A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
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Classification
Broader headings
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MeSH Record
Synonyms
6 entry terms
- PMS-2 Protein
- PMS1 Homolog 2, Mismatch Repair Protein
- PMS2 Protein
- Postmeiotic Segregation Increased-S. cerevisiae-2
- PMS 2 Protein
- Postmeiotic Segregation Increased S. cerevisiae 2
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Adenosine Triphosphatases (2001-2016)
- DNA Repair Enzymes (2001-2016)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Mismatch Repair Endonuclease PMS2. Medical Subject Headings (MeSH). 2026. Unique ID D000070976. http://id.nlm.nih.gov/mesh/2026/D000070976
- Mismatch Repair Endonuclease PMS2. In: Wikidata. https://www.wikidata.org/wiki/Q21118767