Chemicals and Drugs

Mifepristone

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

Chemical Identity

Chemical Information

Molecular Formula
C29H35NO2
Molecular Weight
429.6 g/mol
CAS Registry No.
84371-65-3
IUPAC Name
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
InChIKey
VKHAHZOOUSRJNA-GCNJZUOMSA-N
SMILES
CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
MeSH Unique ID
D015735
Source
PubChem CID 55245

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • Mifegyne
  • Mifeprex
  • Mifégyne
  • R-38486
  • R38486
  • RU-38486
  • RU-486
  • ZK-98296
  • ZK98296
  • R 38486
  • RU 38486
  • RU 486
  • RU38486
  • RU486
  • ZK 98296

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Abortifacient Agents, Steroidal (1975-1989)
  • Contraceptives, Oral, Synthetic (1975-1989)
  • Estrenes (1975-1989)
  • Glucocorticoids/antagonists & inhibitors (1967-1989)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.365.415.580w

AMA Style

References

  1. National Library of Medicine. Mifepristone. Medical Subject Headings (MeSH). 2026. Unique ID D015735. http://id.nlm.nih.gov/mesh/2026/D015735
  2. Mifepristone. In: Wikipedia. https://en.wikipedia.org/wiki/Mifepristone
  3. Mifepristone. In: Wikidata. https://www.wikidata.org/wiki/Q411240
  4. Mifepristone. In: PubChem Compound. CID 55245. https://pubchem.ncbi.nlm.nih.gov/compound/55245