Chemicals and Drugs

Midazolam

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Chemical Identity

Chemical Information

Molecular Formula
C18H13ClFN3
Molecular Weight
325.8 g/mol
CAS Registry No.
59467-70-8
IUPAC Name
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
InChIKey
DDLIGBOFAVUZHB-UHFFFAOYSA-N
SMILES
CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F
MeSH Unique ID
D008874
Source
PubChem CID 4192

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Dormicum
  • Midazolam Hydrochloride
  • Midazolam Maleate
  • Ro 21-3981
  • Versed
  • Hydrochloride, Midazolam
  • Maleate, Midazolam
  • Ro 21 3981
  • Ro 213981

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Azepines (1966-1974)
  • Benzodiazepines (1975-1986)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.080w.575w

MeSH Record

NLM Classification

QV 85

AMA Style

References

  1. National Library of Medicine. Midazolam. Medical Subject Headings (MeSH). 2026. Unique ID D008874. http://id.nlm.nih.gov/mesh/2026/D008874
  2. Midazolam. In: Wikipedia. https://en.wikipedia.org/wiki/Midazolam
  3. Midazolam. In: Wikidata. https://www.wikidata.org/wiki/Q423071
  4. Midazolam. In: PubChem Compound. CID 4192. https://pubchem.ncbi.nlm.nih.gov/compound/4192