Chemicals and Drugs

Microbial Collagenase

A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from HATHEWAYA HISTOLYTICA that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from HATHEWAYA HISTOLYTICA that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

12 entry terms
  • Clostridiopeptidase A
  • Clostridium histolyticum Collagenase
  • Collagenase Clostridium histolyticum
  • Collagenase, Microbial
  • Collalysine
  • Nucleolysin
  • Clostridium histolyticum, Collagenase
  • Collagenase, Clostridium histolyticum
  • histolyticum, Collagenase Clostridium
  • Collagenase-Like Peptidase
  • Collagenase Like Peptidase
  • Peptidase, Collagenase-Like

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

94; was CLOSTRIDIUM HISTOLYTICUM COLLAGENASE 1991-93; was CLOSTRIDIOPEPTIDASE A 1963-90

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.480w.205w.500w
  2. D08.811w.277w.656w.675w.374w.205w.500w

MeSH Record

NLM Classification

QU 136

AMA Style

References

  1. National Library of Medicine. Microbial Collagenase. Medical Subject Headings (MeSH). 2026. Unique ID D003012. http://id.nlm.nih.gov/mesh/2026/D003012
  2. Microbial Collagenase. In: Wikipedia. https://en.wikipedia.org/wiki/Microbial_collagenase
  3. Microbial Collagenase. In: Wikidata. https://www.wikidata.org/wiki/Q13033702