Chemicals and Drugs

Mibefradil

A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.

Chemical Identity

Chemical Information

Molecular Formula
C29H38FN3O3
Molecular Weight
495.6 g/mol
CAS Registry No.
116644-53-2
IUPAC Name
[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate
InChIKey
HBNPJJILLOYFJU-VMPREFPWSA-N
SMILES
CC(C)[C@H]1C2=C(CC[C@@]1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F
MeSH Unique ID
D020748
Source
PubChem CID 60663

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • Mibefradil Dihydrochloride
  • Posicor
  • Ro 40-5967
  • Ro 40 5967
  • Ro 405967

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2000; use MIBEFRADIL 1989-1999

MeSH Record

Previous Indexing

  • Benzimidazoles (1989-1999)
  • Tetrahydronaphthalenes (1989-1999)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.638.960.585w
  2. D03w.633.100.103.618w
  3. D04w.615w.638.960.585w

AMA Style

References

  1. National Library of Medicine. Mibefradil. Medical Subject Headings (MeSH). 2026. Unique ID D020748. http://id.nlm.nih.gov/mesh/2026/D020748
  2. Mibefradil. In: Wikipedia. https://en.wikipedia.org/wiki/Mibefradil
  3. Mibefradil. In: Wikidata. https://www.wikidata.org/wiki/Q6827783
  4. Mibefradil. In: PubChem Compound. CID 60663. https://pubchem.ncbi.nlm.nih.gov/compound/60663