Structured Summary
Abstract
An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
5 entry terms
- Methylmalonyl-CoA Isomerase
- Isomerase, Methylmalonyl-CoA
- Methylmalonyl CoA Isomerase
- Methylmalonyl CoA Mutase
- Mutase, Methylmalonyl-CoA
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
/defic: consider also METHYLMALONIC ACID /urine (IM) + AMINO ACID METABOLISM, INBORN ERRORS (IM)
MeSH Record
History Note
91(75); was see under ISOMERASES 1975-90
MeSH Record
Previous Indexing
- Isomerases (1969-1974)
- Malonates (1969-1974)
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AMA Style
References
- National Library of Medicine. Methylmalonyl-CoA Mutase. Medical Subject Headings (MeSH). 2026. Unique ID D008765. http://id.nlm.nih.gov/mesh/2026/D008765
- Methylmalonyl-CoA Mutase. In: Wikipedia. https://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase
- Methylmalonyl-CoA Mutase. In: Wikidata. https://www.wikidata.org/wiki/Q411008