Structured Summary
Abstract
An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
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Classification
Broader headings
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MeSH Record
Synonyms
4 entry terms
- MMSA Dehydrogenase
- MMSDH
- Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
- Dehydrogenase, MMSA
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1987)
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AMA Style
References
- National Library of Medicine. Methylmalonate-Semialdehyde Dehydrogenase (Acylating). Medical Subject Headings (MeSH). 2026. Unique ID D050646. http://id.nlm.nih.gov/mesh/2026/D050646
- Methylmalonate-Semialdehyde Dehydrogenase (Acylating). In: Wikipedia. https://en.wikipedia.org/wiki/Methylmalonate-semialdehyde_dehydrogenase_(acylating)
- Methylmalonate-Semialdehyde Dehydrogenase (Acylating). In: Wikidata. https://www.wikidata.org/wiki/Q3855607