Chemicals and Drugs

Methylenetetrahydrofolate Dehydrogenase (NAD+)

A NAD-dependent oxidoreductase that catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5,10-methenyl-tetrahdyrofolate. It has been found in a variety of microorganisms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A NAD-dependent oxidoreductase that catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5,10-methenyl-tetrahdyrofolate. It has been found in a variety of microorganisms.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • 5,10-Methylenetetrahydrofolate-Reductase (NADH)
  • 5,10-Methylenetetrahydrofolate:NAD Oxidoreductase
  • Methylenetetrahydrofolate Dehydrogenase (NAD)
  • NADH-Dependent 5,10-Methylenetetrahydrofolate Reductase
  • 5,10 Methylenetetrahydrofolate:NAD Oxidoreductase
  • 5,10-Methylenetetrahydrofolate Reductase, NADH-Dependent
  • NADH Dependent 5,10 Methylenetetrahydrofolate Reductase
  • Oxidoreductase, 5,10-Methylenetetrahydrofolate:NAD

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP)

MeSH Record

History Note

2004; use METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP) 1989-2003; for 5,10-METHYLENETETRAHYDROFOLATE-REDUCTASE (NADH) use METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+) (NM) 1999-2003;

MeSH Record

Previous Indexing

  • Methylenetetrahydrofolate Reductase (1989-2003)
  • Oxidoreductases (1999-2003)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.662.217w

AMA Style

References

  1. National Library of Medicine. Methylenetetrahydrofolate Dehydrogenase (NAD+). Medical Subject Headings (MeSH). 2026. Unique ID D045102. http://id.nlm.nih.gov/mesh/2026/D045102
  2. Methylenetetrahydrofolate Dehydrogenase (NAD+). In: Wikipedia. https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_dehydrogenase_(NAD%2B)
  3. Methylenetetrahydrofolate Dehydrogenase (NAD+). In: Wikidata. https://www.wikidata.org/wiki/Q3380485