Phenomena and Processes

Methyl CpG Binding Domain

A protein domain of about 70 amino acids in length that folds into a sandwich structure consisting of a beta sheet, alpha helix, and C-terminal hairpin loop which forms a hydrophobic methylated-DNA binding patch. It binds to methylated CPG ISLANDS in eukaryotes and occurs with other DNA and CHROMATIN binding domains such as AT-HOOK MOTIFS in eukaryotic DNA BINDING PROTEINS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein domain of about 70 amino acids in length that folds into a sandwich structure consisting of a beta sheet, alpha helix, and C-terminal hairpin loop which forms a hydrophobic methylated-DNA binding patch. It binds to methylated CPG ISLANDS in eukaryotes and occurs with other DNA and CHROMATIN binding domains such as AT-HOOK MOTIFS in eukaryotic DNA BINDING PROTEINS.

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See Also

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Synonyms

1 entry terms
  • Methyl CpG DNA Binding Domain

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • DNA-Binding Proteins (1993-2016)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.438w

AMA Style

References

  1. National Library of Medicine. Methyl CpG Binding Domain. Medical Subject Headings (MeSH). 2026. Unique ID D000070593. http://id.nlm.nih.gov/mesh/2026/D000070593
  2. Methyl CpG Binding Domain. In: Wikipedia. https://en.wikipedia.org/wiki/Methyl-CpG-binding_domain
  3. Methyl CpG Binding Domain. In: Wikidata. https://www.wikidata.org/wiki/Q24787964