Chemicals and Drugs

Methimazole

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

Chemical Identity

Chemical Information

Molecular Formula
C4H6N2S
Molecular Weight
114.17 g/mol
CAS Registry No.
60-56-0
IUPAC Name
3-methyl-1H-imidazole-2-thione
InChIKey
PMRYVIKBURPHAH-UHFFFAOYSA-N
SMILES
CN1C=CNC1=S
MeSH Unique ID
D008713
Source
PubChem CID 1349907

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

24 entry terms
  • 1-Methyl-2-mercaptoimidazole
  • Mercasolyl
  • Mercazolyl
  • Merkazolil
  • Methylmercaptoimidazole
  • Methymazol
  • Thiamazole
  • Thimazol
  • Tiamazol
  • 1 Methyl 2 mercaptoimidazole
  • Favistan
  • Mercazol
  • Mercazole
  • Methizol
  • Metisol
  • Metizol
  • Strumazol
  • Tapazole
  • Thiamazol Henning
  • Thiamazol Hexal
  • Thyrozol
  • Tirodril
  • Henning, Thiamazol
  • Hexal, Thiamazol

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

73(68); was see under THYROID ANTAGONISTS 1963-72

MeSH Record

Previous Indexing

  • Imidazoles (1966-1967)
  • Thyroid Antagonists (1966-1967)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.489w.600w
  2. D03w.383.129w.308.535w

AMA Style

References

  1. National Library of Medicine. Methimazole. Medical Subject Headings (MeSH). 2026. Unique ID D008713. http://id.nlm.nih.gov/mesh/2026/D008713
  2. Methimazole. In: Wikipedia. https://en.wikipedia.org/wiki/Thiamazole
  3. Methimazole. In: Wikidata. https://www.wikidata.org/wiki/Q419663
  4. Methimazole. In: PubChem Compound. CID 1349907. https://pubchem.ncbi.nlm.nih.gov/compound/1349907