Chemicals and Drugs

Methacholine Chloride

A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)

Chemical Identity

Chemical Information

Molecular Formula
C8H18ClNO2
Molecular Weight
195.69 g/mol
CAS Registry No.
62-51-1
IUPAC Name
2-acetyloxypropyl(trimethyl)azanium chloride
InChIKey
JHPHVAVFUYTVCL-UHFFFAOYSA-M
SMILES
CC(C[N+](C)(C)C)OC(=O)C.[Cl-]
MeSH Unique ID
D016210
Source
PubChem CID 6114

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
  • Acetyl-2-methylcholine Chloride
  • Acetyl-beta-methacholine Chloride
  • Mecholine
  • Acetyl 2 methylcholine Chloride
  • Acetyl beta methacholine Chloride
  • Chloride, Methacholine
  • Acetyl-beta-methylcholine
  • Mecholyl
  • Methacholine
  • Provocholine
  • Provokit
  • Acetyl beta methylcholine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Methacholine Compounds (1966-1990)

MeSH Hierarchy

Tree Numbers

  1. D02w.092w.877.883w.555.500
  2. D02w.675w.276.534.500

AMA Style

References

  1. National Library of Medicine. Methacholine Chloride. Medical Subject Headings (MeSH). 2026. Unique ID D016210. http://id.nlm.nih.gov/mesh/2026/D016210
  2. Methacholine Chloride. In: Wikidata. https://www.wikidata.org/wiki/Q26841250
  3. Methacholine Chloride. In: PubChem Compound. CID 6114. https://pubchem.ncbi.nlm.nih.gov/compound/6114