Anatomy

Medium Spiny Neurons

Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.

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Synonyms

4 entry terms
  • Striatal Medium-Sized Spiny Neurons
  • Medium Spiny Neuron
  • Neuron, Medium Spiny
  • Striatal Medium Sized Spiny Neurons

MeSH Record

Aspects Covered

15 allowable subheadings

Indexed with the subheadings chemistry, classification, cytology, drug effects, enzymology, immunology, metabolism, microbiology, parasitology, pathology, physiology, radiation effects, transplantation, ultrastructure, virology.

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History Note

2023

MeSH Record

Previous Indexing

  • Corpus Striatum (1983-2022)
  • Neurons (1983-2022)

MeSH Hierarchy

Tree Numbers

  1. A08w.675w.289.500w
  2. A08w.675w.650w.535w
  3. A11w.671w.285.500w
  4. A11w.671w.650w.535w

AMA Style

References

  1. National Library of Medicine. Medium Spiny Neurons. Medical Subject Headings (MeSH). 2026. Unique ID D000094242. http://id.nlm.nih.gov/mesh/2026/D000094242
  2. Medium Spiny Neurons. In: Wikipedia. https://en.wikipedia.org/wiki/Medium_spiny_neuron
  3. Medium Spiny Neurons. In: Wikidata. https://www.wikidata.org/wiki/Q17152690