Chemicals and Drugs

Mediator Complex

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

MeSH Record

Classification

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MeSH Record

Synonyms

9 entry terms
  • Mediator Transcription Complex
  • Mediator-Like Complex
  • Mediator-Like Complexes
  • TR-Associated Protein (TRAP) Complex
  • TRAP (Thyroid Hormone Associated Protein) Complex
  • Thyroid Hormone-Associated Protein Complex
  • Mediator Like Complex
  • Mediator Like Complexes
  • Thyroid Hormone Associated Protein Complex

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010; for TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 2003-2009

MeSH Record

Previous Indexing

  • RNA Polymerase II (1994-2009)
  • Transcription Factors (1994-2009)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.374w
  2. D12.644w.360.024w.309w
  3. D12.776w.157w.057w.072w
  4. D12.776w.476.024w.388w
  5. D12.776w.660w.551w

AMA Style

References

  1. National Library of Medicine. Mediator Complex. Medical Subject Headings (MeSH). 2026. Unique ID D056892. http://id.nlm.nih.gov/mesh/2026/D056892
  2. Mediator Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Mediator_(coactivator)
  3. Mediator Complex. In: Wikidata. https://www.wikidata.org/wiki/Q14886885