Chemicals and Drugs

Maytansine

An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.

Chemical Identity

Chemical Information

Molecular Formula
C34H46ClN3O10
Molecular Weight
692.2 g/mol
CAS Registry No.
35846-53-8
IUPAC Name
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[acetyl(methyl)amino]propanoate
InChIKey
WKPWGQKGSOKKOO-RSFHAFMBSA-N
SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)C)C)\C)OC)(NC(=O)O2)O
MeSH Unique ID
D008453
Source
PubChem CID 5281828

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Maitansine
  • DMMO-Maytansine
  • Emtansine
  • Maytansinoid DM1
  • Maytansinoid DM4
  • Mertansine
  • N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine
  • Ravtansine
  • Soravtansine
  • DM1, Maytansinoid
  • DM4, Maytansinoid
  • DMMO Maytansine

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(77); was see under OXAZINES 1977-90

MeSH Record

Previous Indexing

  • Morpholines (1966-1975)
  • Oxazines (1976)

MeSH Hierarchy

Tree Numbers

  1. D02w.540w.505w.495w
  2. D04w.345w.295.500w

AMA Style

References

  1. National Library of Medicine. Maytansine. Medical Subject Headings (MeSH). 2026. Unique ID D008453. http://id.nlm.nih.gov/mesh/2026/D008453
  2. Maytansine. In: Wikipedia. https://en.wikipedia.org/wiki/Maitansine
  3. Maytansine. In: Wikidata. https://www.wikidata.org/wiki/Q6720157
  4. Maytansine. In: PubChem Compound. CID 5281828. https://pubchem.ncbi.nlm.nih.gov/compound/5281828