Chemicals and Drugs

Matrix Metalloproteinase 16

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the proteolytic action of PROPROTEIN CONVERTASES. Matrix metalloproteinase 16 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of other MATRIX METALLOPROTEINASES such as the zymogen of MATRIX METALLOPROTEINASE 2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the proteolytic action of PROPROTEIN CONVERTASES. Matrix metalloproteinase 16 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of other MATRIX METALLOPROTEINASES such as the zymogen of MATRIX METALLOPROTEINASE 2.

MeSH Record

Classification

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MeSH Record

Synonyms

17 entry terms
  • MMP-16 Metalloproteinase
  • MMP-X2 Protein
  • MMP16 Metalloproteinase
  • MT3-MMP
  • MT3-Matrix Metalloproteinase
  • Membrane-Type 3 Matrix Metalloproteinase
  • Membrane-Type Matrix Metalloproteinase 3
  • Membrane-Type-3 Matrix Metalloproteinase
  • MMP 16 Metalloproteinase
  • MMP X2 Protein
  • MT3 Matrix Metalloproteinase
  • Matrix Metalloproteinase, Membrane-Type-3
  • Membrane Type 3 Matrix Metalloproteinase
  • Membrane Type Matrix Metalloproteinase 3
  • Metalloproteinase, MMP-16
  • Metalloproteinase, MMP16
  • Metalloproteinase, Membrane-Type-3 Matrix

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007(2005)

MeSH Hierarchy

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AMA Style

References

  1. National Library of Medicine. Matrix Metalloproteinase 16. Medical Subject Headings (MeSH). 2026. Unique ID D053513. http://id.nlm.nih.gov/mesh/2026/D053513
  2. Matrix Metalloproteinase 16. In: Wikidata. https://www.wikidata.org/wiki/Q24787892