Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Mass Secondary Ion Spectrometry

A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.

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Synonyms

9 entry terms
  • Mass Spectrometry, Secondary Ion
  • Mass Spectroscopy, Secondary Ion
  • SIMS Microscopy
  • Secondary Ion Mass Spectrometry
  • Secondary Ion Mass Spectrometry Microscopy
  • Secondary Ion Mass Spectroscopy
  • Secondary Ion Mass Spectroscopy Microscopy
  • Spectrometry, Mass, Secondary Ion
  • Spectroscopy, Mass, Secondary Ion

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Aspects Covered

10 allowable subheadings

Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.

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Indexing Annotation

for SIMS microscopy, coordinate with type of microscopy

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Spectrum Analysis, Mass (1976-1994)

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References

  1. National Library of Medicine. Mass Secondary Ion Spectrometry. Medical Subject Headings (MeSH). 2026. Unique ID D018629. http://id.nlm.nih.gov/mesh/2026/D018629
  2. Mass Secondary Ion Spectrometry. In: Wikipedia. https://en.wikipedia.org/wiki/Secondary-ion_mass_spectrometry
  3. Mass Secondary Ion Spectrometry. In: Wikidata. https://www.wikidata.org/wiki/Q556046