Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Mass Electrospray Ionization Spectrometry

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • ESI Mass Spectrometry
  • Electrospray Ionization Mass Spectrometry
  • Spectrometry, Mass, Electrospray Ionization
  • Mass Spectrometry, ESI
  • Spectrometry, ESI Mass

MeSH Record

Aspects Covered

10 allowable subheadings

Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.

MeSH Record

History Note

2001

MeSH Record

Previous Indexing

  • Spectrum Analysis, Mass (1985-2000)

MeSH Hierarchy

Tree Number

  1. E05.196w.566w.600

AMA Style

References

  1. National Library of Medicine. Mass Electrospray Ionization Spectrometry. Medical Subject Headings (MeSH). 2026. Unique ID D021241. http://id.nlm.nih.gov/mesh/2026/D021241
  2. Mass Electrospray Ionization Spectrometry. In: Wikidata. https://www.wikidata.org/wiki/Q73041617