Chemicals and Drugs

Masoprocol

A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.

Chemical Identity

Chemical Information

Molecular Formula
C18H22O4
Molecular Weight
302.4 g/mol
CAS Registry No.
27686-84-6
IUPAC Name
4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
InChIKey
HCZKYJDFEPMADG-TXEJJXNPSA-N
SMILES
C[C@H](CC1=CC(=C(C=C1)O)O)[C@@H](C)CC2=CC(=C(C=C2)O)O
MeSH Unique ID
D009637
Source
PubChem CID 71398

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • (R*,S*)-4,4'-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol
  • Dihydronorguaiaretic Acid
  • Nordihydroguaiaretic Acid
  • Nordihydroguaiaretic Acid, (R*,S*)-Isomer
  • meso-Nordihydroguaiaretic Acid
  • Acid, meso-Nordihydroguaiaretic
  • meso Nordihydroguaiaretic Acid
  • Actinex

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2014(1987)

MeSH Record

Previous Indexing

  • Catechols (1966-1986)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.389.140.450w.582w
  2. D02w.455w.426w.559w.389.657w.166.550w

AMA Style

References

  1. National Library of Medicine. Masoprocol. Medical Subject Headings (MeSH). 2026. Unique ID D009637. http://id.nlm.nih.gov/mesh/2026/D009637
  2. Masoprocol. In: Wikipedia. https://en.wikipedia.org/wiki/Masoprocol
  3. Masoprocol. In: Wikidata. https://www.wikidata.org/wiki/Q6783851
  4. Masoprocol. In: PubChem Compound. CID 71398. https://pubchem.ncbi.nlm.nih.gov/compound/71398