Chemicals and Drugs

Maraviroc

A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for membrane fusion and cellular entry.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for membrane fusion and cellular entry.

Chemical Identity

Chemical Information

Molecular Formula
C29H41F2N5O
Molecular Weight
513.7 g/mol
CAS Registry No.
376348-65-1
IUPAC Name
4,4-difluoro-N-[(1S)-3-[(1S,5R)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
InChIKey
GSNHKUDZZFZSJB-HLMSNRGBSA-N
SMILES
CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
MeSH Unique ID
D000077592
Source
PubChem CID 3002977

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
  • Selzentry
  • UK-427,857
  • UK-427857
  • UK 427,857
  • UK 427857
  • UK427,857
  • UK427857

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (2005)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.392.368w.367.726w
  2. D03w.383.129w.799w.682w

AMA Style

References

  1. National Library of Medicine. Maraviroc. Medical Subject Headings (MeSH). 2026. Unique ID D000077592. http://id.nlm.nih.gov/mesh/2026/D000077592
  2. Maraviroc. In: Wikipedia. https://en.wikipedia.org/wiki/Maraviroc
  3. Maraviroc. In: Wikidata. https://www.wikidata.org/wiki/Q421369
  4. Maraviroc. In: PubChem Compound. CID 3002977. https://pubchem.ncbi.nlm.nih.gov/compound/3002977