Chemicals and Drugs

Mannose-Binding Protein-Associated Serine Proteases

Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

19 entry terms
  • MASP
  • MASP Proteases
  • MASPs
  • MBL-Associated Serine Proteases
  • MBP-Associated Serine Protease
  • Mannan-Binding Lectin Serine Proteases
  • Mannose-Binding Protein-Associated Serine Protease
  • MBL Associated Serine Proteases
  • MBP Associated Serine Protease
  • Mannan Binding Lectin Serine Proteases
  • Mannose Binding Protein Associated Serine Protease
  • Proteases, MASP
  • Serine Protease, MBP-Associated
  • Serine Proteases, MBL-Associated
  • MASP-Related Protein
  • MBP-Associated Serine Protease-Related Protein
  • MASP Related Protein
  • MBP Associated Serine Protease Related Protein
  • Protein, MASP-Related

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

see SCR for organism-specific terms

MeSH Record

History Note

2006 (1994)

MeSH Record

Previous Indexing

  • Mannose-Binding Lectins (1992-2005)
  • Serine Endopeptidases (1992-2005)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.501w
  2. D08.811w.277w.656w.959w.350.501w
  3. D12.776w.124w.486.274.045.387.875w

AMA Style

References

  1. National Library of Medicine. Mannose-Binding Protein-Associated Serine Proteases. Medical Subject Headings (MeSH). 2026. Unique ID D050606. http://id.nlm.nih.gov/mesh/2026/D050606
  2. Mannose-Binding Protein-Associated Serine Proteases. In: Wikipedia. https://en.wikipedia.org/wiki/Mannose-binding_protein-associated_serine_protease
  3. Mannose-Binding Protein-Associated Serine Proteases. In: Wikidata. https://www.wikidata.org/wiki/Q16878362