Phenomena and Processes

Mannose-Binding Lectin Complement Pathway

Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

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Classification

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See Also

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Synonyms

17 entry terms
  • Complement Pathway, Mannose-Binding Lectin
  • Lectin-Complement Pathway
  • Mannan-Binding Lectin Complement Pathway
  • Mannan-Binding Lectin Pathway (Complement Activation)
  • Complement Pathway, Mannose Binding Lectin
  • Lectin Complement Pathway
  • Lectin Pathway, Mannan-Binding (Complement Activation)
  • Lectin Pathways, Mannan-Binding (Complement Activation)
  • Lectin-Complement Pathways
  • Mannan Binding Lectin Complement Pathway
  • Mannan Binding Lectin Pathway (Complement Activation)
  • Mannan-Binding Lectin Pathways (Complement Activation)
  • Mannose Binding Lectin Complement Pathway
  • Pathway, Lectin-Complement
  • Pathway, Mannan-Binding Lectin (Complement Activation)
  • Pathways, Lectin-Complement
  • Pathways, Mannan-Binding Lectin (Complement Activation)

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Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

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History Note

2003

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Previous Indexing

  • Complement Activation (1989-2002)

MeSH Hierarchy

Tree Number

  1. G12.274.849

AMA Style

References

  1. National Library of Medicine. Mannose-Binding Lectin Complement Pathway. Medical Subject Headings (MeSH). 2026. Unique ID D037582. http://id.nlm.nih.gov/mesh/2026/D037582
  2. Mannose-Binding Lectin Complement Pathway. In: Wikidata. https://www.wikidata.org/wiki/Q70710267