Chemicals and Drugs

Mannich Bases

Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • Mannich Base
  • Base, Mannich
  • Bases, Mannich

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

IM general only

MeSH Record

History Note

91(77); was see under AMINES 1977-90

MeSH Record

Previous Indexing

  • Amines (1966-1976)

MeSH Hierarchy

Tree Numbers

  1. D02w.092w.650w
  2. D02w.522w.650w

AMA Style

References

  1. National Library of Medicine. Mannich Bases. Medical Subject Headings (MeSH). 2026. Unique ID D008352. http://id.nlm.nih.gov/mesh/2026/D008352
  2. Mannich Bases. In: Wikipedia. https://en.wikipedia.org/wiki/Mannich_base
  3. Mannich Bases. In: Wikidata. https://www.wikidata.org/wiki/Q391433