Psychiatry and Psychology

Major Depressive Disorder

Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every day; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every day; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

18 entry terms
  • Clinical Depression
  • Depressive Disorder, Major
  • Major Depression Disorder
  • Depression Disorders, Major
  • Depressions, Clinical
  • Depressive Disorders, Major
  • Disorder, Major Depressive
  • Disorders, Major Depression
  • Disorders, Major Depressive
  • Major Depressive Disorders
  • Depression, Involutional
  • Melancholia, Involutional
  • Paraphrenia, Involutional
  • Psychosis, Involutional
  • Depressions, Involutional
  • Melancholias, Involutional
  • Paraphrenias, Involutional
  • Psychoses, Involutional

MeSH Record

Aspects Covered

31 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, rehabilitation, surgery, therapy, urine, virology.

MeSH Record

History Note

81; was PSYCHOSES, INVOLUTIONAL 1963-80; MELANCHOLIA, INVOLUTIONAL was see under PSYCHOSES, INVOLUTIONAL 1963-78

MeSH Hierarchy

Tree Number

  1. F03w.600w.300.375w

MeSH Record

NLM Classification

WM 171.5

AMA Style

References

  1. National Library of Medicine. Major Depressive Disorder. Medical Subject Headings (MeSH). 2026. Unique ID D003865. http://id.nlm.nih.gov/mesh/2026/D003865
  2. Major Depressive Disorder. In: Wikipedia. https://en.wikipedia.org/wiki/Major_depressive_disorder
  3. Major Depressive Disorder. In: Wikidata. https://www.wikidata.org/wiki/Q42844