Diseases

MPTP Poisoning

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • MPTP Neurotoxicity Syndrome
  • MPTP-Induced Parkinsonism
  • Neurotoxicity Syndrome, MPTP
  • Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • MPTP Induced Parkinsonism
  • MPTP Neurotoxicity Syndromes
  • Neurotoxicity Syndromes, MPTP
  • Parkinsonism, MPTP-Induced
  • Poisoning, MPTP
  • MPTP-Induced Degeneration of the Striatum
  • MPTP Induced Degeneration of the Striatum

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

not for animal models of Parkinson disease induced by MPTP: index MPTP-INDUCED EXPERIMENTAL PARKINSONISM

MeSH Record

History Note

2000

MeSH Record

Previous Indexing

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/poisoning (1990-1999)
  • Parkinson Disease, Secondary (1983-1999)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.079w.862w.800.300
  2. C10w.228w.662w.600w.700.250
  3. C10w.720.606
  4. C25.723.705.400

AMA Style

References

  1. National Library of Medicine. MPTP Poisoning. Medical Subject Headings (MeSH). 2026. Unique ID D020267. http://id.nlm.nih.gov/mesh/2026/D020267
  2. MPTP Poisoning. In: Wikidata. https://www.wikidata.org/wiki/Q54926390