Structured Summary
Abstract
A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
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Synonyms
4 entry terms
- HIV-1-Tat Interactive Protein Tip60
- HTATIP
- KAT5 (TIP60) Protein
- HIV 1 Tat Interactive Protein Tip60
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Acetyltransferases (2002-2017)
- Histone Acetyltransferases (2005-2017)
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References
- National Library of Medicine. Lysine Acetyltransferase 5. Medical Subject Headings (MeSH). 2026. Unique ID D000074443. http://id.nlm.nih.gov/mesh/2026/D000074443
- Lysine Acetyltransferase 5. In: Wikidata. https://www.wikidata.org/wiki/Q21112551