Chemicals and Drugs

Lymphocyte Function-Associated Antigen-1

An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.

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Synonyms

6 entry terms
  • Integrin alphaLbeta2
  • LFA-1
  • Leukocyte Function Associated Antigen-1
  • Antigen-1, Lymphocyte Function-Associated
  • Lymphocyte Function Associated Antigen 1
  • alphaLbeta2, Integrin

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1991

MeSH Record

Previous Indexing

  • Antigens, Differentiation (1988-1990)
  • Receptors, Leukocyte-Adhesion (1989-1990)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.074.937w
  2. D09w.400w.430w.890w.200w.625w.550w
  3. D12.776w.395w.550w.200w.074.937w
  4. D12.776w.395w.550w.200w.625w.550w
  5. D12.776w.543w.550w.200w.093.937w
  6. D12.776w.543w.550w.200w.625w.550w
  7. D12.776w.543w.750w.705w.408w.600.400w
  8. D12.776w.543w.750w.705w.877w.550w
  9. D23.050w.301.350w.074.400w
  10. D23.050w.301.350w.625w.550w

AMA Style

References

  1. National Library of Medicine. Lymphocyte Function-Associated Antigen-1. Medical Subject Headings (MeSH). 2026. Unique ID D016169. http://id.nlm.nih.gov/mesh/2026/D016169
  2. Lymphocyte Function-Associated Antigen-1. In: Wikipedia. https://en.wikipedia.org/wiki/Lymphocyte_function-associated_antigen_1
  3. Lymphocyte Function-Associated Antigen-1. In: Wikidata. https://www.wikidata.org/wiki/Q4042438