Phenomena and Processes

Loss of Function Mutation

A mutation that causes a decrease in or elimination of a gene product's activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mutation that causes a decrease in or elimination of a gene product's activity.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

8 entry terms
  • Leaky Mutation
  • Null Mutation
  • Leaky Mutations
  • Mutation, Leaky
  • Mutation, Null
  • Mutations, Leaky
  • Mutations, Null
  • Null Mutations

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Mutation (1989-2017)

MeSH Hierarchy

Tree Number

  1. G05.365w.590w.538

AMA Style

References

  1. National Library of Medicine. Loss of Function Mutation. Medical Subject Headings (MeSH). 2026. Unique ID D000073658. http://id.nlm.nih.gov/mesh/2026/D000073658
  2. Loss of Function Mutation. In: Wikidata. https://www.wikidata.org/wiki/Q15832730